Research Articles 46 Escort Infrared Door Key. Yıl Cad. Nanoparticles are solid colloidal particles ranging in size from 10 to nm having high surface area-to-volume ratio which allows them for efficient interaction with biological systems. Nanoparticles offer many benefits in comparison to larger particles such as increased surface-to-volume ratio and increased magnetic properties. Nanomaterials hold the potential to revolutionize critical domains Escort Infrared Door Key Biomedicine, Drug Delivery, and Pharmaceutical Analysis. These particles can be functionalized with specific molecules to target diseased cells or tissues, enhancing the efficacy of drugs while minimizing side effects. For instance, gold nanoparticles conjugated with antibodies can be used for targeted cancer therapy, delivering therapeutic agents directly to tumor cells. Similarly, drugs Escort Infrared Door Key within nanoparticles can be protected from premature degradation and released in a controlled manner at the target site improving their drug solubility, and enhance cellular uptake, leading to better therapeutic effect in treatment strategies. Polymeric nanoparticles, liposomes, and micelles are some examples of commonly used nanocarriers for drug delivery. Nanomaterials are finding increasing applications in pharmaceutical analysis and can be employed as highly sensitive detection probes for drugs, metabolites, and biomarkers. Additionally, nanomaterials can be used for the separation and purification of biomolecules, facilitating accurate and efficient analysis. As research continues to overcome current challenges, nanomaterials unique properties hold immense promise for revolutionizing healthcare and improving patient outcomes. The eye, which is essential for vision, is susceptible to diseases such as diabetic retinopathy, age-related macular degeneration, glaucoma, and dry eye syndrome. These conditions can significantly impair quality of life and lead to blindness. Traditional treatments for eye diseases, especially eye drops, have low bioavailability and short retention times on the ocular surface. To overcome these problems, new drug delivery systems such as hydrogels, contact lenses, microneedles, and nanosystems have been developed to increase drug penetration and maintain therapeutic effects. Drug delivery to the eye can occur via systemic, topical, intravitreal, intracorneal, subconjunctival, and suprachoroidal routes, each with different advantages and limitations. Systemic administration often results in low ocular drug concentrations and systemic side effects. Topical eye drops are easy to apply and localized, but face difficulties in absorption and retention. Intravitreal and suprachoroidal injections provide targeted delivery to the posterior segment but are invasive and carry infection risks. Subconjunctival and intracorneal routes offer less invasive alternatives with improved targeting capabilities. Nanosystems and controlled-release technologies hold promise for overcoming current barriers and aim to increase drug bioavailability, extend release times, and improve patient compliance. Overall, advancing drug delivery methods is important for effective treatment of both anterior and posterior segment eye diseases. Thiazole derivatives have attracted much attention in medicinal chemistry due to their diverse pharmacological activities. This study provides an overview of the latest synthetic derivatives of thiazole and their therapeutic applications. Innovative methodologies have been adopted to enhance the structural diversity and optimize the pharmacological properties of thiazolebased compounds. These synthetic derivatives exhibit a broad spectrum of therapeutic activities, and understanding the essential features responsible for the observed pharmacological effects has been pivotal in structureactivity relationship studies. Drug development efforts have focused on modulating thiazole derivatives for improved bioavailability, selectivity, and reduced toxicity. This abstract highlights the potential of thiazole derivatives in targeting specific biological activity, paving the way for developing innovative therapeutic agents. Thiazole moiety as a heterocyclic compound was studied for its different pharmacological actions. The derivatives obtained from thiazole have diverse therapeutic actions along with antimicrobial activity, antitubercular activity, antidiabetic activity, anticonvulsant, anti-inflammatory actions, and antitumor activities. The mechanism of actions of all these activities is also studied by the researcher to provide scientific evidence and validation of their actions. Utilization of synthetic chemistry for exploration of various pharmacological potential of thiazole derivatives will lead the future pharmacologists to a newer dimension for new drug discovery and also these derivatives can be further optimized for the development of alternative options for the treatment of various diseases. The versatility of thiazole scaffolds presents promising opportunities for discovering new drugs with enhanced efficacy and improved pharmacokinetic profiles. As researchers continue to delve into the synthesis and pharmacological evaluation of thiazole derivatives, their significance in modern drug design and therapy becomes increasingly evident. Key Words: Thiazole, heterocyclic, antitubercular, antimicrobial, anti-inflammatory.
2020 Volume 45, Issue 3
Volume 46, Issue 2 – FABAD Journal of Pharmaceutical Sciences Key Words: Biomedicine, Nanoparticles, Carbon nanotubes, Drug Delivery. Anticancer Property of Orthosiphon stamineus Benth. This issue is published electronically on December CONTENTS. Ocular Drug Delivery Routes: Diseases Overview and Advanced. Research Articles. Contact – FABAD Journal of Pharmaceutical SciencesThese activities include anticonvulsant, antimicrobial, antituberculosis, antiviral, etc. In vitro cell viability evaluation with L mouse fibroblast cell line confirmed the biocompatibility of prepared formulations, and the anticancer effect of novel nanoemulgel formulations was presented in BF10 mouse melanoma cell line. J Transl Med ; The outcomes of this study allow us to conclude that even though lyophilization and spray drying can be used to enhance solubility, lyophilization showed superior results. Mainly, imaging techniques are utilized to diagnose CE. Key Words: exendin-4, diabetes, oral route, pulmonary route,transdermal route, nanocarriers.
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She alleged that she had been raped by two men on 31 July and 1 August , when she was 14 years and 10 months old. Key Words: Biomedicine, Nanoparticles, Carbon nanotubes, Drug Delivery. The ensuing investigation came to the. Ocular Drug Delivery Routes: Diseases Overview and Advanced. This issue is published electronically on December CONTENTS. Anticancer Property of Orthosiphon stamineus Benth. The aircraft platform will be equipped with two turboprop engines and critical payloads such as EO/IR camera, AESA radar, Beyond Line of Sight (satellite). Research Articles.Therefore, patients using statins are generally advised to avoid grapefruit juice consumption. Carbon monoxide CO is a toxic gas, has a beneficial effect on cells in low doses. Polymeric nanoparticles, liposomes, and micelles are some examples of commonly used nanocarriers for drug delivery. Metabolomics analysis was performed by using gas chromatography-mass spectrometry. Wound dressings made of biodegradable polymers do not require a second procedure for removal. Beligo or Bligo is the name of Benincasa hispida Thunb. In this study, our aim was to determine some biological activities of the ethanolic and methanolic extracts of Salvia sclarea L. Previous studies demonstrated that the increase in HDL was found to be higher in the aerobic group in adults and children CO donors control the amount and gradual release of carbon monoxide. Traditional treatments for eye diseases, especially eye drops, have low bioavailability and short retention times on the ocular surface. Early diagnosis and differentiation of infection from other pathological conditions such as cancer and inflammation play a critical role in treating the infection in acute stages. Further studies are needed to investigate this matter in more detail. It was concluded that polyphenolic extracts obtained from galls formed in J. As a result, the anticontractile function of PVAT continues in adult rats and limits the contraction with a tonic inhibitory effect. Results The demographic and body composition variables of pre-test and post-tests for the participants are presented in Table 1. Thiazole derivatives have attracted much attention in medicinal chemistry due to their diverse pharmacological activities. Research focusing on the treatments of brain disorders involving glucose metabolic dysfunctions is also discussed. Santosh A. Wound dressings made of biodegradable polymers do not require a second procedure for removal. Child Obes ; The Fluconazole-loaded elastic liposome gel was prepared successfully and was found to be a good choice over conventional gel formulation for the treatment of keratomycosis. Key Words: Mesalamine, pellets, Moringa oleifera gum, Cyamopsis tetragonolobus gum, in vivo colon targeting. Brain results did not show oxidative stress in terms of lipid peroxidation but the decreased AChE activities and, unaltered PON activities accompanied with increased amyloidogenesis are accepted as an early response of neurodegeneration in older rats. Overall, advancing drug delivery methods is important for effective treatment of both anterior and posterior segment eye diseases. The mechanism of actions of all these activities is also studied by the researcher to provide scientific evidence and validation of their actions.